Premium
Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons
Author(s) -
Kullmann Jan A,
Neumeyer Alexander,
Gurniak Christine B,
Friauf Eckhard,
Witke Walter,
Rust Marco B
Publication year - 2012
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.211
Subject(s) - cerebellum , cerebellar cortex , granule cell , neuronal migration , neuroscience , microbiology and biotechnology , biology , cell migration , cell , central nervous system , genetics , dentate gyrus
Cerebellar granule neurons (CGNs) exploit Bergmann glia (BG) fibres for radial migration, and cell–cell contacts have a pivotal role in this process. Nevertheless, little is known about the mechanisms that control CGN–BG interaction. Here we demonstrate that the actin‐binding protein profilin1 is essential for CGN–glial cell adhesion and radial migration. Profilin1 ablation from mouse brains leads to a cerebellar hypoplasia, aberrant organization of cerebellar cortex layers and ectopic CGNs. Conversely, neuronal progenitor proliferation, tangential migration of neurons and BG morphology appear to be independent of profilin1. Our mouse data and the mapping of developmental neuropathies to the chromosomal region of PFN1 suggest a similar function for profilin1 in humans.