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Metabolic signals regulate SIRT1 expression
Author(s) -
Chalkiadaki Angeliki,
Guarente Leonard
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.179
Subject(s) - regulator , transcription factor , creb , biology , key (lock) , computational biology , nutrient sensing , microbiology and biotechnology , transcription (linguistics) , genetics , signal transduction , gene , ecology , linguistics , philosophy
SIRT1 is a key metabolic regulator in response to nutrient availability. Here, Chalkiadaki and Guarente comment on a report published online this month in which J. Auwerx and colleagues show how SIRT1 transcription is controlled by the antagonistic actions of CREB and ChREBP in response to the energetic status of the cell.