A genetic  in vivo  system to detect asymmetrically distributed RNA | Zendy

JayaNandanan N | Zendy; Gavis Elizabeth R | Zendy; Riechmann Veit | Zendy; Leptin Maria | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A genetic in vivo system to detect asymmetrically distributed RNA

Author(s) -

JayaNandanan N,

Gavis Elizabeth R,

Riechmann Veit,

Leptin Maria

Publication year - 2011

Publication title -

embo reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.584

H-Index - 184

eISSN - 1469-3178

pISSN - 1469-221X

DOI - 10.1038/embor.2011.178

Subject(s) - rna , messenger rna , biology , subcellular localization , genome , gene , computational biology , microbiology and biotechnology , in vivo , gene expression , genetics

Many RNAs show polarized or otherwise non‐random subcellular distributions. To create a method for genome‐wide genetic screens for RNAs with asymmetric subcellular distributions, we have combined methods for gene tagging and live imaging of messenger RNA (mRNA). A pilot screen in a highly polarized, differentiated cell in the Drosophila larva, the branched terminal cell of the tracheal system, demonstrates the feasibility of the method for identifying new asymmetrically localized mRNAs in vivo .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research