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SIRT3 deacetylase: the Jekyll and Hyde sirtuin
Author(s) -
Silberman Dafne M,
Mostoslavsky Raul
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2011.147
Subject(s) - sirt3 , sirtuin , pharmacology , biology , chemistry , acetylation , biochemistry , gene
Mitochondrial deacetylase SIRT3 protects against oxidative damage. In an article published online this month in EMBO reports , it is shown to also aggravate paracetamol‐induced liver toxicity, calling for caution in trying to pharmacologically enhance SIRT3 activity.