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Laying the foundation for epithelia: insights into polarized basement membrane deposition
Author(s) -
Eastburn Dennis J,
Mostov Keith E
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.54
Subject(s) - basement membrane , microbiology and biotechnology , biology , epithelium , function (biology) , genetics
Epithelial tissues are essential for the function of almost all major organs and altering their polarized architecture leads to a variety of diseases. The directed deposition of basement membrane proteins is a crucial but poorly understood process, important to maintain epithelial structure. In this issue of EMBO reports , the Drosophila gene Scarface is shown to regulate it.