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Tame affairs: domesticated transposase and domestic pigs
Author(s) -
Volff JeanNicolas
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.31
Subject(s) - domestication , transposase , biology , transposable element , genetics , genome , gene , repressor , transcription factor
Long thought to be genomic junk, domesticated transposons have turned out to be an incredible source of new genes. Two studies—one this issue of EMBO reports—show that a domesticated hAT transposase is a transcriptional repressor of IGF2 that regulates muscle growth and has over 1,200 additional putative targets in the mammalian genome.