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Silencing in trans : position matters in fission yeast
Author(s) -
Gullerova Monika,
Proudfoot Nick J
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.24
Subject(s) - rna interference , gene silencing , biology , gene , mechanism (biology) , genetics , yeast , schizosaccharomyces , schizosaccharomyces pombe , trans acting , microbiology and biotechnology , saccharomyces cerevisiae , rna , philosophy , epistemology , mutant
The distinction in RNAi‐mediated gene silencing between metazoans —which mostly use a post‐transcriptional RNAi mechanism— and fission yeast —which use a transcriptional RNAi mechanism— seems to be less clear‐cut than previously thought. Robin Allshire's group has recently published in EMBO reports that S. pombe can repress gene expression in trans , which is reminiscent of mammalian post‐transcriptional gene silencing.