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Evolutionary origins of oxygen sensing in animals
Author(s) -
Rytkönen Kalle T,
Storz Jay F
Publication year - 2011
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.192
Subject(s) - oxygen , oxygen metabolism , biology , evolutionary biology , biological evolution , oxygen evolution , chemistry , genetics , organic chemistry , electrode , electrochemistry
Oxygen is required for aerobic energy production but its levels have to be tightly regulated to avoid deleterious effects. Thus, animals have evolved mechanisms to monitor and respond to fluctuations in oxygen availability. Here, the evolution of the HIF system is discussed in light of a report that reveals its presence in the simplest animal.