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The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila
Author(s) -
CobrerosReguera Laura,
FernándezMiñán Ana,
FernándezEspartero Cecilia H,
LópezSchier Hernán,
GonzálezReyes Acaimo,
MartínBermudo María D
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.156
Subject(s) - border cells , microbiology and biotechnology , biology , cell migration , transcription factor , regulator , drosophila (subgenus) , cadherin , cell , gene , genetics
Stationary‐to‐migratory transitions of epithelial cells have a key role in development and tumour progression. Border cell migration is a powerful system in which to investigate this transition in living organisms. Here, we identify the Ste20‐like kinase misshapen ( msn ) as a novel regulator of border‐cell migration in Drosophila . Expression of msn in border cells is independent of the transcription factor slow border cells and of inputs from all pathways that are known to control border‐cell migration. The msn gene functions to modulate the levels and/or distribution of Drosophila E‐cadherin to promote the invasive migratory behaviour of border cells.