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Maternal phosphatidylinositol 3‐kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
Author(s) -
Zheng Wenjing,
Gorre Nagaraju,
Shen Yan,
Noda Tetsuo,
Ogawa Wataru,
Lundin Eva,
Liu Kui
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.144
Subject(s) - embryogenesis , phosphatidylinositol , biology , microbiology and biotechnology , embryonic stem cell , kinase , embryo , blastocyst , pi3k/akt/mtor pathway , pten , phosphoinositide 3 kinase , signal transduction , genetics , gene
Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two‐cell‐stage arrest of embryos lacking maternal 3‐phosphoinositide‐dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double‐mutant females. Our study identifies maternal phosphatidylinositol 3‐kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice.