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Argonaute MID domain takes centre stage
Author(s) -
Faehnle Christopher R,
JoshuaTor Leemor
Publication year - 2010
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2010.110
Subject(s) - argonaute , biology , rna , rna interference , gene , genetics
Two recent papers, one in EMBO reports and one in Nature give us the first eukaryotic structures of Argonaute MID domains; providing a structural basis for the 5′‐nucleotide recognition of the guide strand and a possible explanation for the allosteric regulation of RNA binding.