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Apoptosis: it's BAK to VDAC
Author(s) -
Shore Gordon C.
Publication year - 2009
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2009.249
Subject(s) - voltage dependent anion channel , microbiology and biotechnology , bacterial outer membrane , mitochondrion , biology , apoptosis , genetics , gene , escherichia coli
VDAC's role in Bak‐dependent mitochondrial outer membrane permeabilization (MOMP) is controversial. Gordon Shore makes sense of it all in light of an EMBO reports paper that shows that VDAC mediates mitochondrial recruitment of Bak, thereby controlling tBid‐induced MOMP.