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Protein quality control—linking the unfolded protein response to disease
Author(s) -
Cyr Douglas M.,
Hebert Daniel N.
Publication year - 2009
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2009.224
Subject(s) - protein folding , unfolded protein response , protein quality , biology , disease , microbiology and biotechnology , computational biology , endoplasmic reticulum , medicine , biochemistry , pathology
The proper folding of proteins is essential for cellular homeostasis and prevention of an ever‐growing number of diseases. Here, the authors highlight recent breakthroughs in the study of the unfolded protein response and new strategies to combat the diseases caused by its malfunction.