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Retracted: Switching of chromatin‐remodelling complexes for oestrogen receptor‐α
Author(s) -
Okada Maiko,
Takezawa Shinichiro,
Mezaki Yoshihiro,
Yamaoka Ikuko,
Takada Ichiro,
Kitagawa Hirochika,
Kato Shigeaki
Publication year - 2008
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2008.55
Subject(s) - transactivation , chromatin , cell cycle , microbiology and biotechnology , nuclear receptor , regulator , chromatin remodeling , biology , repressor , cell growth , function (biology) , receptor , cell , transcription factor , genetics , gene
The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand‐dependent transactivation of ERs requires several nuclear co‐regulator complexes; however, the cell‐cycle‐dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERα at G2/M was lowered. Biochemical approaches showed that ERα associated with two discrete classes of ATP‐dependent chromatin‐remodelling complex in a cell‐cycle‐dependent manner. The components of the NuRD‐type complex were identified as G2/M‐phase‐specific ERα co‐repressors. Thus, our results indicate that the transactivation function of ERα is cell‐cycle dependent and is coupled with a cell‐cycle‐dependent association of chromatin‐remodelling complexes.