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RYBP stabilizes p53 by modulating MDM2
Author(s) -
Chen Deng,
Zhang Jianbing,
Li Mao,
Rayburn Elizabeth R,
Wang Hui,
Zhang Ruiwen
Publication year - 2009
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2008.231
Subject(s) - mdm2 , suppressor , regulator , microbiology and biotechnology , ubiquitin , dna damage , repressor , dna , cancer cell , chemistry , biology , cancer research , cancer , cell culture , biochemistry , transcription factor , genetics , gene
The mouse double minute 2 (MDM2)–p53 interaction regulates the activity of p53 and is a potential target for human cancer therapy. Here, we report that RYBP (RING1‐ and YY1‐binding protein), a member of the polycomb group (PcG), interacts with MDM2 and decreases MDM2‐mediated p53 ubiquitination, leading to stabilization of p53 and an increase in p53 activity. RYBP induces cell‐cycle arrest and is involved in the p53 response to DNA damage. Expression of RYBP is decreased in human cancer tissues compared with adjacent normal tissues. These results show that RYBP is a new regulator of the MDM2–p53 loop and that it has tumour suppressor activity.