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GAS, a new glutamate‐rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function
Author(s) -
Liang Jing,
Zhang Hua,
Zhang Yu,
Zhang Ying,
Shang Yongfeng
Publication year - 2009
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2008.223
Subject(s) - nuclear receptor coactivator 1 , nuclear receptor coactivator 2 , nuclear receptor coactivator 3 , coactivator , transactivation , biology , microbiology and biotechnology , estrogen receptor alpha , transcription factor , nuclear receptor , estrogen receptor , cancer research , genetics , gene , cancer , breast cancer
Steroid receptor coactivators (SRCs) exert profound effects on animal development and physiology. Genetic ablation experiments indicate that various SRC proteins might have differential physiological roles; however, clear evidence of functional specificity has not yet been shown at the molecular level. Here we report the identification of a new SRC1 interacting protein, glutamate‐rich coactivator interacting with SRC1 (GAS), which contains a central glutamate‐rich region and has transactivation activity. Interestingly, GAS interacts only with SRC1, and not with glucocorticoid receptor interacting protein 1 (GRIP1) or amplified in breast cancer 1 (AIB1), the other two members of the SRC family. It interacts with oestrogen receptor‐α (ERα) and participates in both oestrogen receptor‐regulated gene transcription and oestrogen‐stimulated G1/S cell‐cycle transition. Our data thus indicate that GAS is a new transcription cofactor and that different SRCs are associated with distinct secondary cofactors.