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Function and regulation of protein neddylation
Author(s) -
Rabut Gwénaël,
Peter Matthias
Publication year - 2008
Publication title -
embo reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.584
H-Index - 184
eISSN - 1469-3178
pISSN - 1469-221X
DOI - 10.1038/embor.2008.183
Subject(s) - neddylation , ubiquitin , nedd8 , posttranslational modification , function (biology) , microbiology and biotechnology , biology , biochemistry , ubiquitin ligase , enzyme , gene
Neddylation is the post‐translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protein neddylation and highlight the mechanisms that ensure the specificity of neddylation over ubiquitination. As numerous neddylation substrates probably remain to be discovered, we propose some criteria that could be used as guidelines for the characterization of neddylated proteins.