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Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
Author(s) -
Takayama Kenichi,
HorieInoue Kuniko,
Katayama Shintaro,
Suzuki Takashi,
Tsutsumi Shuichi,
Ikeda Kazuhiro,
Urano Tomohiko,
Fujimura Tetsuya,
Takagi Kiyoshi,
Takahashi Satoru,
Homma Yukio,
Ouchi Yasuyoshi,
Aburatani Hiroyuki,
Hayashizaki Yoshihide,
Inoue Satoshi
Publication year - 2013
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2013.99
Subject(s) - biology , corepressor , prostate cancer , repressor , androgen receptor , long non coding rna , cancer research , non coding rna , rna , regulation of gene expression , microbiology and biotechnology , gene expression , cancer , gene , genetics
High‐throughput techniques have identified numerous antisense (AS) transcripts and long non‐coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, we report an androgen‐responsive long ncRNA, CTBP1‐AS , located in the AS region of C‐terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. CTBP1‐AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1‐AS promotes both hormone‐dependent and castration‐resistant tumour growth. Mechanistically, CTBP1‐AS directly represses CTBP1 expression by recruiting the RNA‐binding transcriptional repressor PSF together with histone deacetylases. CTBP1‐AS also exhibits global androgen‐dependent functions by inhibiting tumour‐suppressor genes via the PSF‐dependent mechanism thus promoting cell cycle progression. Our findings provide new insights into the functions of ncRNAs that directly contribute to prostate cancer progression.