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It cuts two ways: microtubule loss during Alzheimer disease
Author(s) -
Jean Daphney C,
Baas Peter W
Publication year - 2013
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2013.219
Subject(s) - biology , microtubule , disease , alzheimer's disease , microbiology and biotechnology , genetics , medicine
Microtubule loss contributes to nervous system degeneration during Alzheimer disease. New findings report that abnormal tau invasion into dendrites, triggered by Amyloid β, results in excess severing of microtubules by spastin.