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Author(s) -
Chaumeil Julie,
Skok Jane A
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.64
Subject(s) - biology , computational biology
By sequencing TCRα transcripts from naive mouse CD8+ T cells, Genolet et al show that the TCRα repertoire is diverse and that rearrangement of all possible Vα‐Jα combinations can occur. This overturns a long held view in the field that recombination of the Tcra locus occurs in a co‐ordinate sequential bidirectional manner.