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The simplest explanation: passive DNA demethylation in PGCs
Author(s) -
Smith Zachary D,
Meissner Alexander
Publication year - 2013
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.349
Subject(s) - stem cell biology , stem cell , biology , classics , history , genetics , embryo , reproductive technology , embryogenesis
During primordial germ cell (PGC) specification, global epigenetic modifications restructure the genome in a coordinated fashion. Novel evidence supports passive erasure, rather than active mechanisms, for the removal of epigenetic marks.