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Long non‐coding RNA gadd7 interacts with TDP‐43 and regulates Cdk6 mRNA decay
Author(s) -
Liu Xuefeng,
Li Dan,
Zhang Weimin,
Guo Mingzhou,
Zhan Qimin
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.292
Subject(s) - biology , messenger rna , rna , nonsense mediated decay , non coding rna , transcription (linguistics) , rna editing , microbiology and biotechnology , genetics , computational biology , gene , rna splicing , linguistics , philosophy
Long non‐coding RNAs (lncRNAs) transcribed extensively from the genome have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulation of the cell‐cycle G1/S checkpoint following DNA damage, a key step in the maintenance of genomic fidelity. Here we show that growth‐arrested DNA damage‐inducible gene 7 ( gadd7 ), a DNA damage‐inducible lncRNA, regulates the G1/S checkpoint in response to UV irradiation. Interestingly, UV‐induced gadd7 directly binds to TAR DNA‐binding protein (TDP‐43) and interferes with the interaction between TDP‐43 and cyclin‐dependent kinase 6 ( Cdk6 ) mRNA, resulting in Cdk6 mRNA degradation. These findings demonstrate a role for gadd7 in controlling cell‐cycle progression and define a novel mechanism by which lncRNAs modulate mRNA expression at the post‐transcriptional level by altering mRNA stability.