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Polyvalent DP1 keeps the Wnt pathway neat and tidy
Author(s) -
Fagotto François
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.201
Subject(s) - biology , wnt signaling pathway , microbiology and biotechnology , signal transduction
Two opposite actions of DP1 on the Wnt signalling pathway, one negative in the cytoplasm and one positive in the nucleus, contribute to the generation of sharp responses to Wnt gradients.