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Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny
Author(s) -
Ren Jie,
Martienssen Robert A
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.172
Subject(s) - biology , heterochromatin , heterochromatin protein 1 , genetics , destiny (iss module) , computational biology , dna , chromatin , physics , astronomy
A recent study published in Molecular Cell reports on a heterochromatin‐specific checkpoint that captures and primes heterochromatic RNAs for degradation. The authors propose HP1Swi6 to facilitate this by competitive binding to mRNA transcripts respective histone tails.