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Innate immunity: regulation of caspases by IAP‐dependent ubiquitylation
Author(s) -
Falschlehner Christina,
Boutros Michael
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.148
Subject(s) - biology , innate immune system , immunity , caspase , ubiquitin , microbiology and biotechnology , immunology , apoptosis , genetics , immune system , programmed cell death , gene
DIAP2‐mediated ubiquitylation of the pro‐apoptotic initiator caspase Dredd converts it to an activator of the NfκB pathway required for innate immune signalling in Drosophila.