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Epigenetic reprogramming: Prdm14 hits the accelerator
Author(s) -
Geijsen Niels
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.117
Subject(s) - reprogramming , epiblast , sox2 , biology , epigenetics , embryonic stem cell , induced pluripotent stem cell , homeobox protein nanog , stem cell , germ layer , genetics , gastrulation , cell , gene
The cooperation of Prdm14/Klf2 accelerates the reversion from mouse epiblast stem cells to a naive pluripotent state, offering mechanistic insights into key determinants of reprogramming in early germ cells.