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Shifting a complex debate on γ ‐secretase cleavage and Alzheimer's disease
Author(s) -
Golde Todd E,
Ran Yong,
Felsenstein Kevin M
Publication year - 2012
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2012.111
Subject(s) - neuroscience , translational research , psychology , medicine , pathology
Bart de Strooper and colleagues examine the effects of different Alzheimer's disease (AD) causing mutations on γ‐Secretase intramembrane cleavage. These data should settle the long‐standing debate of how PSEN/γ‐secretase contributes to AD.