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Immune synapses: mitochondrial morphology matters
Author(s) -
Junker Christian,
Hoth Markus
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.72
Subject(s) - biology , mitochondrion , microbiology and biotechnology
Mitochondria accumulate at the immune synapse (IS), but it is not clear how this is achieved. Francisco Sánchez‐Madrid and colleagues report in this issue of The EMBO Journal that the mitochondrial fission factor DRP1, which regulates mitochondria morphology, also controls mitochondrial localization at the IS and thereby modulates IS formation and downstream signalling.