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TRAPping telomerase within the intestinal stem cell niche
Author(s) -
Pech Matthew F,
Artandi Steven E
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.51
Subject(s) - medical school , biology , library science , medicine , medical education , computer science
Recent work from Hans Clevers' lab reveals high telomerase activity and telomere length in dividing LGR5‐positive intestinal stem cells. They further report random chromosome segregation and thus challenge the ‘immortal strand’ hypothesis at least for this stem cell population.