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Negative regulation of immune responses on the fly
Author(s) -
Lee KwangZin,
Ferrandon Dominique
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.47
Subject(s) - drosophila melanogaster , humanities , biology , library science , philosophy , genetics , gene , computer science
The Toll and the IMD pathways are key regulators of innate immunity in Drosophila . A paper in this issue of the EMBO Journal reports that activation of the Ras/MAPK pathway negatively regulates the IMD pathway and limits the magnitude of the innate immune response during an infection.