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The erythroid/myeloid lineage fate paradigm takes a new player
Author(s) -
Xu Jian,
Orkin Stuart H
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.45
Subject(s) - hematology , medical school , medicine , oncology , gerontology , medical education
This issue of The EMBO Journal features a new paradigm for cell lineage commitment. By studying early haematopoiesis in zebrafish, Roger Patient and colleagues characterize the Tif1 gamma‐ligase as a context‐specific regulator of Gata1/PU1‐driven fate decisions.
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