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Human pluripotent stem cells decouple respiration from energy production
Author(s) -
ShyhChang Ng,
Zheng Yuxiang,
Locasale Jason W,
Cantley Lewis C
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.436
Subject(s) - biology , induced pluripotent stem cell , respiration , microbiology and biotechnology , stem cell , energy metabolism , genetics , embryonic stem cell , botany , gene , endocrinology
In human pluripotent stem cells, uncoupling protein 2 switches energy metabolism from respiration to glycolysis preventing their premature differentiation.