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Target of γ‐secretase modulators, presenilin marks the spot
Author(s) -
Crump Christina J,
Johnson Douglas S,
Li YueMing
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.410
Subject(s) - library science , medicine , computer science
GSMs reduce the production of Aβ42 and are promising compounds for the treatment of Alzheimer disease. However, the target and mechanism of GSMs have been controversial. A study published in this issue of The EMBO Journal adds insight into this and shows that GSMs bind directly to the catalytic subunit of γ‐secretase leading to altered cleavage of APP.