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A novel nuclear miRNA mediated modulation of a non‐coding antisense RNA and its cognate sense coding mRNA
Author(s) -
Rossi John J
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.373
Subject(s) - biology , microrna , argonaute , gene silencing , messenger rna , rna , rna induced silencing complex , non coding rna , rna interference , computational biology , gene , genetics , microbiology and biotechnology
MicroRNAs control gene expression by inhibition of protein translation and by mRNA degradation. Now, a new mode of action for miRNAs is reported: nuclear‐localized miRNAs target non‐coding antisense transcripts via the Ago2 slicer complex.
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