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Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis
Author(s) -
Greenberg Andrew S,
Kraemer Fredric B,
Soni Krishnakant G,
Jedrychowski Mark P,
Yan QingWu,
Graham Christine E,
Bowman Thomas A,
Mansur Ayla
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.371
Subject(s) - biology , lipolysis , adipocyte , lipid droplet , perilipin , microbiology and biotechnology , biochemistry , adipose tissue
Optic Atrophy 1 (OPA1) is well known as a regulator of mitochondrial dynamics. Now, a new function of OPA1 is uncovered: recruiting protein kinase A to lipid droplets, thereby controlling the activity of perilipin, and hence lipolysis.
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