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Jarid2 regulates mouse epidermal stem cell activation and differentiation
Author(s) -
Mejetta Stefania,
Morey Lluis,
Pascual Gloria,
Kuebler Bernd,
Mysliwiec Matthew R,
Lee Youngsook,
Shiekhattar Ramin,
Di Croce Luciano,
Benitah Salvador Aznar
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.265
Subject(s) - biology , humanities , library science , art , computer science
Jarid2 is required for the genomic recruitment of the polycomb repressive complex‐2 (PRC2) in embryonic stem cells. However, its specific role during late development and adult tissues remains largely uncharacterized. Here, we show that deletion of Jarid2 in mouse epidermis reduces the proliferation and potentiates the differentiation of postnatal epidermal progenitors, without affecting epidermal development. In neonatal epidermis, Jarid2 deficiency reduces H3K27 trimethylation, a chromatin repressive mark, in epidermal differentiation genes previously shown to be targets of the PRC2. However, in adult epidermis Jarid2 depletion does not affect interfollicular epidermal differentiation but results in delayed hair follicle (HF) cycling as a consequence of decreased proliferation of HF stem cells and their progeny. We conclude that Jarid2 is required for the scheduled proliferation of epidermal stem and progenitor cells necessary to maintain epidermal homeostasis.