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TFEBulous control of traffic by mTOR
Author(s) -
Jacinto Estela
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.258
Subject(s) - pi3k/akt/mtor pathway , biology , tfeb , mtorc1 , microbiology and biotechnology , mechanistic target of rapamycin , biogenesis , lysosome , genetics , gene , biochemistry , signal transduction , enzyme
mTOR is an important regulator of cell growth in response to nutrients and growth signals. A study published in this issue of The EMBO Journal and a recent study by Settembre et al published in Science reveal how growth signals mediated by mTOR and other protein kinases such as MAPK can converge on TFEB to modulate endosome biogenesis and trafficking.