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Developmental regulation of CYCA2s contributes to tissue‐specific proliferation in Arabidopsis
Author(s) -
Vanneste Steffen,
Coppens Frederik,
Lee EunKyoung,
Donner Tyler J,
Xie Zidian,
Van Isterdael Gert,
Dhondt Stijn,
De Winter Freya,
De Rybel Bert,
Vuylsteke Marnik,
De Veylder Lieven,
Friml Jiří,
Inzé Dirk,
Grotewold Erich,
Scarpella Enrico,
Sack Fred,
Beemster Gerrit T S,
Beeckman Tom
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.240
Subject(s) - biology , arabidopsis , microbiology and biotechnology , genetics , computational biology , gene , mutant
In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell‐cycle machinery is largely unknown. Here, we characterize plant A2‐type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine‐tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2;3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell‐cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.