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Policing Parkin with a UblD
Author(s) -
Liu Fen,
Walters Kylie J
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.223
Subject(s) - parkin , biology , genetics , medicine , disease , parkinson's disease , pathology
Parkin, a ubiquitin ligase of the RING‐IBR‐RING family, is mutated in familial Parkinsonism. Exciting recent reports transform our thinking of its catalytic activity, and reveal a new autoinhibitory mechanism that is abolished by disease mutations
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