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A mad partner for Shugoshin in meiosis
Author(s) -
Yu Hongtao
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.217
Subject(s) - cohesin , biology , mad2 , spindle checkpoint , anaphase , kinetochore , chromosome segregation , meiosis , genetics , microbiology and biotechnology , chromosome , gene
The centromeric cohesin protector Shugoshin (Sgo) and the spindle checkpoint protein Mad2 are known to act in distinct pathways for ensuring accurate chromosome segregation during eukaryotic cell division. A study in this issue of The EMBO Journal describes an unexpected physical interaction between vertebrate Sgo and Mad2, and hints to their potential mutual regulation in meiosis.