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P53 conformational switching for selectivity may reveal a general solution for specific DNA binding
Author(s) -
Tubbs Julie L,
Tainer John A
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.133
Subject(s) - biology , dna , dna binding protein , selectivity , genetics , plasma protein binding , computational biology , biophysics , gene , biochemistry , transcription factor , catalysis
This article highlights the role of conformational changes in p53 in dictating DNA‐binding specificity as described by the Halazonetis laboratory in this issue and extends this principle to other systems such as proteins involved in recognizing specific types of DNA damage.