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Is PrP the road to ruin?
Author(s) -
Barton Kelly A,
Caughey Byron
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.129
Subject(s) - biology , microbiology and biotechnology , signalling , programmed cell death , protein folding , feature (linguistics) , computational biology , genetics , apoptosis , linguistics , philosophy
One feature of neurodegenerative disorders is the accumulation of β‐sheet‐rich misfolded proteins, but how these proteins trigger cell death is not clear. Resenberger and coworkers report in this issue that the cellular prion protein can mediate neurotoxic signalling of various β‐sheet‐rich conformers.