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AMPK and autophagy get connected
Author(s) -
Hardie D Grahame
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.12
Subject(s) - biology , autophagy , ampk , microbiology and biotechnology , genetics , protein kinase a , phosphorylation , apoptosis
This ‘Have you seen?’ features two recent publications establishing a direct molecular link from metabolic stress to activation of cellular autophagy. The studies from the Shaw‐lab (published in Science) and the Guan‐lab (NCB) report stress‐induced AMPK‐activation that triggers ULK1‐phosphorylation, the mammalian orthologue of the autophagy regulator Atg1.