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Wnt signalling: W hat T he X @# is WTX?
Author(s) -
RegimbaldDumas Yannik,
He Xi
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2011.101
Subject(s) - biology , wnt signaling pathway , genetics , signal transduction
In this issue of The EMBO Journal , Tanneberger et al demonstrate that Amer1/WTX, a tumour suppressor protein previously known for promoting β‐catenin degradation and thus antagonizing Wnt signalling, is also required for LRP6 receptor phosphorylation and therefore activation of Wnt signalling.