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Salmonella vacuole maturation: PIKfyve leads the way
Author(s) -
Gutierrez Maximiliano G
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.41
Subject(s) - biology , salmonella , vacuole , microbiology and biotechnology , genetics , bacteria , cytoplasm
In this issue of The EMBO Journal, a study from Rohan Teasdale’s laboratory provides evidence that PIKfyve, a PtdIns D5-kinase, is required for maturation of Salmonellacontaining vacuole (SCV) and Salmonella replication. This report sheds light on a novel mechanism that mediates fusion of both macropinosomes and SCV with lysosomal/ late endosomal organelles.
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