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Fis1, Bap31 and the kiss of death between mitochondria and endoplasmic reticulum
Author(s) -
Wang Bing,
Nguyen Mai,
Chang Natasha C,
Shore Gordon C
Publication year - 2011
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.352
Subject(s) - endoplasmic reticulum , biology , microbiology and biotechnology , mitochondrion , kiss (tnc) , fis1 , biochemistry , mitochondrial fusion , mitochondrial dna , computer network , computer science , gene
A study in this issue of The EMBO Journal sheds light on how mitochondria–ER dynamics, which affect various cell functions, regulate Bax/Bak‐driven apoptosis within the complex milieu of the cell. In cell death, these organelles engage in an unanticipated two‐way communication, from mitochondria to ER and back again.