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Nuclear FoxO1 inflames insulin resistance
Author(s) -
Dominy John E,
Puigserver Pere
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.305
Subject(s) - biology , insulin resistance , foxo1 , resistance (ecology) , insulin , genetics , transcription factor , endocrinology , gene , ecology
FoxO1 regulates the transcription of genes involved in diabetes, cancer and ageing. In this issue of The EMBO Journal , Olefsky and colleagues report that FoxO1 also causes inflammation by regulating the pro‐inflammatory Tlr4 signalling pathway in macrophages. Insulin‐mediated activation of Akt inactivates FoxO1 and thereby limits the inflammatory response.