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Bach2: plasma‐cell differentiation takes a break
Author(s) -
Kallies Axel,
Nutt Stephen L
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.282
Subject(s) - biology , microbiology and biotechnology , genetics , computational biology
While progress has been made in our understanding of how the transition of mature B cells to antibody‐producing cells, plasma cells, is regulated, less is known about what regulates the timing of this transition. A paper in this issue of the EMBO Journal reports that the transcription factor Bach2 regulates the timing of plasma cell differentiation by suppressing Blimp1 expression.