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A splicing mastermind for EMT
Author(s) -
Tavanez Joao P,
Valcárcel Juan
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.234
Subject(s) - biology , rna splicing , computational biology , genetics , evolutionary biology , gene , rna
The importance of developmentally‐regulated, tissue‐specific alternative splicing is discussed here in the context of the epithelial splicing factors ESRP1 and 2, whose activity is critical for the maintenance of epithelial identity, and must be down‐regulated during epithelial‐mesenchymal transition.