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ICT1 comes to the rescue of mitochondrial ribosomes
Author(s) -
Haque Md Emdadul,
Spremulli Linda L
Publication year - 2010
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1038/emboj.2010.22
Subject(s) - biology , ribosome , mitochondrial ribosome , mitochondrion , microbiology and biotechnology , genetics , rna , gene
In the current issue, [Richter et al (2010)][1] show that mammalian mitochondrial ribosomes contain a ribosomal protein (ICT1) that acts as a ribosome‐dependent, codon‐independent peptidyl‐tRNA hydrolase. This ribosomal protein can rescue ribosomes stalled on mRNAs lacking a termination codon. [1]: #ref-3